Commercial Real Estate for Sale and Lease in San Mateo, CA

Find commercial real estate across San Mateo, CA: office space, retail storefronts, industrial buildings, warehouses, and mixed-use. Compare asking prices and lease rates, view photos, and connect with the listing brokerage.

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Commercial property in San Mateo, CA

$1,780,000

422 Peninsula Avenue, San Mateo, CA

3,456 sqft · Built 1954 · 6,098 sqft lot · Zoned EA00E2

422-426 Peninsula Ave presents a rare owner-user or investment opportunity located on the border of San Mateo and Burlingame (Currently 100% Vacant, Situated on a 6,098 square foot…

$14,950,000

710 Laurel Avenue, San Mateo, CA

21,345 sqft · Built 1959 · 23,087 sqft lot · Zoned R6

MNM Realty Group is pleased to offer 14 tenant-in-common (TIC) positions in Park Laurel Apartments.

$2,000

2140 S El Camino Real, San Mateo, CA

Mixed Use · Built 1925 · 4,000 sqft lot · Zoned C30000

Ground-floor commercial space located along El Camino Real offering excellent visibility, strong street frontage, and convenient access to Highway 92.

$1,295,000

67 E 4th Avenue, San Mateo, CA

900 sqft · Built 1952 · 900 sqft lot · Zoned CB000D

Rare Downtown San Mateo Retail/Owner-User Opportunity located in the heart of Downtown San Mateo, 67 East 4th Avenue presents a unique opportunity to acquire a highly visible…

$1,999,000

228 State Street, San Mateo, CA

4,556 sqft · Built 1926 · 7,500 sqft lot · Zoned RM0000

Excellent five-unit investment opportunity ideally located between Downtown San Mateo and Downtown Burlingame, offering convenient access to shopping, dining, Caltrain, major…

$2,495,000

616 S Amphlett Boulevard, San Mateo, CA

6,098 sqft · Built 1935 · 6,020 sqft lot · Zoned CH00C4

616 S Amphlett Blvd represents a unique opportunity to acquire a well-located mixed-use investment property in the heart of San Mateo.

$1,100,000

180 South Boulevard, San Mateo, CA

1,834 sqft · Built 1948 · 4,767 sqft lot · Zoned c2-1

$1,648,000

869 WOODSIDE WAY, San Mateo, CA

Built 1942 · 5.88% cap rate · 2,222 sqft lot · Zoned ML00

Recently remodeled (2023) and never occupied commercial space, offering a rare move-in ready mixed-use opportunity in the heart of San Mateo Village and a central Peninsula…

$8,900,000

100106 N Bayshore Boulevard, San Mateo, CA

Price reduced · 24,592 sqft · Built 1960 · 38 units · 24,944 sqft lot · Zoned Commercial Multifamily

GROSS RENTS INCREASED (10-1-26) FROM $63,000/YEAR TO $68,000/YEAR --- PRICE REDUCTION OF $550,000!! -- The Knights Inn Apartments, located at 100-106 N.

$2,500,000

San Mateo, CA 94402

Price reduced · 5,624 sqft · Built 1958 · 7 units · 7,728 sqft lot · Zoned R3

Fiesta Gardens Six unit building in very good condition. Upper units have decks; lower units have patio yards.

$3,600

San Mateo, CA 94401

Mixed Use · Built 1960 · 1,800 sqft lot · Zoned Comm

Commercial Store, Market uses, Shop Space or Tech Space lots of opportunity uses for this close in space to Downtown Burlingame and San Mateo.

$20,230

1009 S Claremont Street, San Mateo, CA

Mixed Use · Built 1989 · 5,350 sqft lot · Zoned ML00M

2 story building w/auto garage door. Separate computer server rooms w/independent HVAC systems. Alarm systems. Camera surveillance inside & out. Electronic door access system.

$2,150,000

216 N San Mateo Drive

Price reduced · 2,796 sqft · Built 1900 · 8,409 sqft lot · Zoned EA00E2

$1,899,000

19 E 41st Place, San Mateo, CA

Price reduced · 2,447 sqft · Built 1957 · 6 units · 7,699 sqft lot · Zoned R4

19 E 41st Place is a well-maintained six-unit multifamily asset in the desirable San Mateo submarket.

$2,750,000

739 N Amphlett Boulevard, San Mateo, CA

Price reduced · 4,586 sqft · Built 1958 · 6 units · 4,313 sqft lot · Zoned R40000

An exceptional investment opportunity in the heart of San Mateo! This commercial multi-unit property at 739 N.

$3,000,000

420 Peninsula Avenue 2, San Mateo, CA

4,000 sqft · Built 2024 · 12,197 sqft lot · Zoned EA00E2

This newly built medical dental condo is situated on the bustling San Mateo - Burlingame border. Condo is thoughtfully renovated with quality material and finishes throughout.

$5,425,000

735 N Amphlett Boulevard, San Mateo, CA

Price reduced · 4,586 sqft · Built 1958 · 12 units · 4,313 sqft lot · Zoned R40000

An exceptional investment opportunity in the heart of San Mateo! This commercial multi-unit property at 735 & 739 N.

$3,500

420 Peninsula Avenue 3, San Mateo, CA

Mixed Use · Price reduced · Built 2019 · 12,212 sqft lot · Zoned EA00E2

This newly constructed medical/dental condo is ideally located on the vibrant San Mateo - Burlingame border.

$3,600

420 Peninsula Avenue 2, San Mateo, CA

Mixed Use · Price reduced · Built 2019 · 12,212 sqft lot · Zoned EA00E2

This newly constructed medical/dental condo is ideally located on the vibrant San Mateo - Burlingame border.

$3,000,000

420 Peninsula Avenue 3, San Mateo, CA

4,000 sqft · Built 2019 · 12,212 sqft lot · Zoned EA00E2

This newly constructed medical/dental condo is ideally located on the vibrant San Mateo Burlingame border.

Showing 20 listings in San Mateo, CA. View them all on the map to filter by price, beds, and more.

What's on the market in San Mateo right now

Listed for sale now

For lease now

Asking prices of listings currently active on Nalren in San Mateo, CA, refreshed daily.

Commercial property types in San Mateo

Mixed-Use: 5 for lease

Counts and asking prices of listings currently active on Nalren in San Mateo, CA, refreshed daily. Asking prices, not valuations.

Recently sold commercial properties in San Mateo, CA

Closed sales (last 24 months)

$2,060,000

Median sold price

$425

Median sold price per sqft

Latest closed sales

125 South Boulevard: Sold for $3,300,000 on Aug 11, 2026 (10,707 sqft)
20012003 Parrott Drive: Sold for $5,650,000 on Jul 8, 2026 (14,316 sqft)
2830 Flores Street: Sold for $8,225,000 on Jan 22, 2026 (15,311 sqft)
1950 Ivy Street: Sold for $2,060,000 on Dec 30, 2025 (4,428 sqft)
128 N B Street: Sold for $1,279,750 on Dec 12, 2025 (1,400 sqft)
1956 Ivy Street: Sold for $2,049,000 on Nov 21, 2025 (4,192 sqft)
320 N San Mateo Drive 2: Sold for $150,000 on Oct 17, 2025 (3,726 sqft)
231 Villa Terrace: Sold for $3,900,000 on Jul 21, 2025 (11,260 sqft)
43 N Idaho Street: Sold for $1,748,000 on Dec 30, 2024 (4,116 sqft)

Sold prices are MLS-reported closed sales recorded in San Mateo, CA over the last 24 months, not an estimate or valuation of any property.

Commercial real estate in cities near San Mateo

Burlingame (14) South San Francisco (8) Redwood City (19) Palo Alto (16) San Leandro (14) Hayward (31) San Francisco (46) Oakland (99)

Commercial real estate guides

Commercial real estate loans in California Cap rate, NOI & GRM explained How to sell commercial property NNN vs. gross lease Modified gross leases explained Full-service gross leases & base years All commercial lease types compared

Buying, selling, or leasing commercial property in San Mateo, CA?

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Frequently asked questions: San Mateo, CA

Is there commercial space for lease in San Mateo, CA?

Yes. Nalren currently lists 5 commercial spaces for lease in San Mateo, CA (5 mixed-use). Lease rates vary by term and structure (NNN vs. gross), so compare per-listing terms and contact the listing brokerage directly.

What have commercial properties sold for in San Mateo, CA?

9 commercial properties closed in San Mateo, CA in the last 24 months, from $150,000 to $8,225,000 with a median sold price of $2,060,000 and a median of $425 per square foot. These are MLS-reported closed sales, not an estimate or valuation of any property.

How many commercial real estate listings are in San Mateo, CA?

Nalren currently has 20 commercial real estate listings in San Mateo, CA. New listings are added throughout the day. Open the Nalren app to see everything and set alerts.

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